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    Each year, the Council of Europe invites its partners to focus on a specific topic on the occasion of the European Day. The Council of Europe partners with a wide audience to celebrate the European Day including member states, civil society organisations and national parliaments. This webpage provides access to the various initiatives organised by these partners displayed below under Activities allowing all to share their products to generate good practices. Children are increasingly exploring and expressing their sexuality through information and communication technologies ICTs , in particular social media and messaging applications. The Council of Europe promotes a large variety of awareness raising tools videos, communication material, information websites, brochures, … prepared by our partners in various languages.
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    The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis

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    The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis

    Intriguing sex differences both in multiple sclerosis MS susceptibility and its disease course may offer important insights into MS disease pathophysiology, prevention and treatment. In this review, we first summarize the key sex-related differences in MS risk, heritability and disease progression. One promising hypothesis we explore is whether sexually-dimorphic responsiveness to cultural and environmental changes may explain the observation of an increasing female:male sex ratio in MS. We then review the evidence for hormonal modulation of MS, during such transitions as puberty and pregnancy.
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    Background: Why are women more susceptible to multiple sclerosis, but men have worse disability progression? Sex differences in disease may be due to sex hormones, sex chromosomes, or both. Objective: Determine whether differences in sex chromosomes can contribute to sex differences in multiple sclerosis using experimental autoimmune encephalomyelitis. Methods: Sex chromosome transgenic mice, which permit the study of sex chromosomes not confounded by differences in sex hormones, were used to examine an effect of sex chromosomes on autoimmunity and neurodegeneration, focusing on X chromosome genes.
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